ArticleFrontiers in immunology2026
Single-cell and spatial transcriptomics reveal transplant-associated T cells and myeloid cells in human liver transplantation.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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11 authors.
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Abstract
Background: Liver transplantation is the only effective way for end-stage liver disease. Rejection remains the leading cause of graft failure. The dynamic changes of intrahepatic immune cells involved in rejection are not completely understood. Methods: We integrated single-cell RNA sequencing and spatial transcriptomics (ST) to analyze graft tissues from multiple stages of human liver transplantation. ST enabled high-resolution mapping of immune cell states and spatial distribution within liver grafts. Results: We identified several transplantation-associated T cell (taT) subsets, including CD4 Conclusion: These findings highlight the potential roles and spatial distribution of taT subsets in rejecting liver grafts, providing insights into local immune regulation and the development of targeted therapeutic strategies.
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