ArticleFrontiers in immunology2026
In the diffuse large B-cell lymphoma microenvironment, SIRT1 is upregulated and correlated with a pro-inflammatory macrophage signature and autophagy-related gene expression.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous blood cancer and one of the most frequent non-Hodgkin lymphomas of B-cell origin. As it has a complex, macrophage-rich immune microenvironment, we wanted to determine the role of autophagy, in which incoming threats are sequestered/removed and damaged cell constituents and debris are recycled, and metabolic sensors, such as sirtuins (SIRTs), in this cancer. Therefore, we determined the autophagy status in primary DLBCL samples using publicly available transcriptomic data and validated these results by immunohistochemistry and immunofluorescence analyses of patients' tissue microarrays. We found that autophagy components and SIRTs were upregulated in the DLBCL microenvironment, particularly in the resting (M0) and pro-inflammatory (M1) macrophage subtypes. Moreover, the expression of autophagy factors was positively correlated with that of
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