Evidence map›Paper›PMID 41716389›Full record

ReviewFrontiers in immunology2026

B cells and iBALT in TB immunity & pathogenesis.

Taru S Dutt, Robert Krause, David Hertz, Marcela Henao-Tamayo, Alasdair Leslie, Bianca Schneider

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Neonatal CD19Frontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Taru S Dutt *Division of Laboratory Medicine, Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Robert Krause *Africa Health Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
David Hertz *Host Determinants in Lung Infections, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Marcela Henao-Tamayo *Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Alasdair Leslie *Africa Health Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Bianca Schneider *Host Determinants in Lung Infections, Priority Research Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Funding

Non-tuberculous mycobacterium and B cells in the stimulation of ectopic germinal centers and immunological control of pulmonary tuberculosisR00AI173401 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Taru S. Dutt · 2025 to 2026
$497k
NIAID NIH HHS R00 AI173401
6 · The paper itself

Abstract

B cells play a crucial role in immunity against various infectious diseases. However, their role in tuberculosis (TB) has been largely understudied. Emerging evidence suggests that B cells actively shape immune responses in TB. Beyond their classical functions, B cells contribute to the formation of inducible bronchus-associated lymphoid tissue (iBALT), a tertiary lymphoid structure (TLS) that enhances localized immune responses in the lungs. As iBALT is a site for B-T cell interactions and the generation of high-affinity antibodies, recent studies suggest that sex differences in iBALT formation influence TB immunity. This review synthesizes evidence from both TB and non-TB models to highlight the expanding role of B cells and iBALT, underscoring their potential implications for vaccine development and immunotherapy.

Indexed as

B-LymphocytesMycobacterium tuberculosisTertiary Lymphoid StructuresTuberculosisAnimalsHumansLungT-LymphocytesantibodiesB cellsiBALTsex differencesTLStuberculosis

Identifiers

PMID41716389
PMCPMC12913489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.