ArticleFrontiers in immunology2026
Disrupted immune senescence in early pregnancy is associated with recurrent pregnancy loss.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immune system adaptation plays a crucial role in pregnancy success. Cellular senescence, linked to immune dysfunction and chronic inflammation, may contribute to adverse pregnancy outcomes but remains poorly characterized during early gestation, at the systemic level. Objective: To characterize senescence marker expression in peripheral leukocyte subsets in early pregnancy and to examine its association with miscarriage history and functionally distinct T helper cell populations. Methods: This cross-sectional study included 52 pregnant women: 18 with recurrent pregnancy loss (≥2 miscarriages), 18 with one prior loss, and 16 controls with no loss history. Peripheral blood leukocytes were analyzed using an automated hematology analyzer and by flow cytometry for senescence markers (p16, p21, p53) and major T-cell subsets. Group differences were tested by ANOVA or Kruskal-Wallis test, as appropriate and exploratory Spearman correlation analyses examined associations between miscarriage number, senescent subsets, and T-cell populations. Results: Senescent cells were detected as percentages of granulocytes, monocytes, and lymphocytes, with granulocytes exhibiting the highest senescence expression. A consistent p21>p16>p53 expression pattern across immune subsets was observed in controls, suggesting a physiologic senescence hierarchy. This organization was progressively disrupted in miscarriage groups. A stepwise increase with miscarriage number was observed across subsets. Significant differences were observed in the median percentage of p16 Conclusion: Pregnancy loss history is associated with both quantitative and qualitative alterations in immune senescence profiles, including organizational remodeling of peripheral immune senescence. Analysis of proinflammatory and regulatory T-cell subsets revealed additional associations, suggesting immune senescence may interact with adaptive immune polarization in early pregnancy. These findings highlight disrupted immune senescence as a potential component of immune maladaptation and identify senescent immune cells as candidate biomarkers for recurrent miscarriage.
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