ReviewJournal of clinical and experimental dentistry2025
Impact of calcium hydroxide as an intracanal medicament on postoperative pain in diabetic and non-diabetic patients with symptomatic apical periodontitis and pulp necrosis - a double-blind randomized controlled clinical trial.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: This study aimed to evaluate the effect of calcium hydroxide Ca(OH)2 as an intracanal medicament on postoperative pain in diabetic and non-diabetic patients with symptomatic apical periodontitis and pulp necrosis. Material and Methods: A double-blind, prospective randomized controlled clinical trial was conducted on 96 patients (48 diabetics and 48 non-diabetics) aged 30-65 years. Patients were allocated into four groups: Group A (non-diabetic with Ca(OH)2), Group B (diabetic with Ca(OH)2), Group C (non-diabetic without Ca(OH)2), and Group D (diabetic without Ca(OH)2). Endodontic treatment was performed, and postoperative pain was assessed using the Heft Parker Visual Analog Scale (HPVAS) at 6, 24, 48, 72, 96, 120, 144, and 168 hours. Statistical analysis included Kruskal-Wallis, Dunn's post hoc, and Kaplan-Meier survival tests. Results: At baseline and 6 hours, pain scores were comparable across groups (p > 0.05). From 24 to 120 hours, significant differences were observed (p < 0.05), with Group A showing the fastest and most consistent pain reduction, while Group D reported the highest pain levels. Groups B and C demonstrated intermediate relief with comparable trends. By 168 hours, all groups achieved near-zero pain levels. Kaplan-Meier analysis confirmed the earliest median pain relief in Group A (72 hours), delayed recovery in Groups B and C (120 hours), and the slowest in Group D. Conclusions: Calcium hydroxide significantly reduced postoperative pain, with the greatest benefit in non-diabetic patients. Its effect was more decisive than diabetes status, underscoring its clinical significance as a reliable intracanal medicament for managing postoperative pain in both healthy and systemically compromised patients.
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