ReviewJournal of clinical and experimental dentistry2025
Histological evaluation of palatal donor site healing with leukocyte-platelet-rich fibrin versus collagen sponge.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The palate is the primary donor site for autogenous connective tissue grafts in periodontal and peri-implant plastic surgery, yet healing by secondary intention often results in morbidity. Collagen sponge (CS) and leukocyte-platelet-rich fibrin (L-PRF) have been proposed to enhance donor site repair, but comparative histological evidence in humans remains scarce. Objective: To compare the histological characteristics of palatal donor site healing following coverage with CS or L-PRF. Material and Methods: A retrospective cross-sectional histological study was performed on palatal biopsies collected four months after connective tissue graft harvesting covered with CS (n = 9) or L-PRF (n = 9). Epithelial type and thickness, lamina propria thickness, submucosal composition, inflammatory infiltrate, vascular congestion, and edema were evaluated using hematoxylin-eosin staining. Results: Both biomaterials supported uneventful healing without necrosis or severe inflammation. Compared with CS, L-PRF was associated with thicker epithelium, a higher frequency of hyperparakeratinization, and the presence of orthokeratinization. Lamina propria thickness was slightly greater in L-PRF, while fibrous submucosa predominated in both groups. Mild leukocyte infiltration and transient edema were more common with L-PRF, suggesting a more active regenerative response. Conclusions: CS and L-PRF both promoted favorable palatal donor site healing. L-PRF demonstrated histological features consistent with enhanced tissue regeneration, likely due to its growth factor content. These preliminary findings warrant validation in randomized controlled trials with larger sample sizes.
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