Evidence map›Paper›PMID 41716352›Full record

ArticleMaterials today. Bio2026

The multilayer coatings on polylactic acid implants spatiotemporally regulates the microenvironment to enhance antibacterial and osseointegration capacity.

Jinyang Lyu, Shuaiqi Jiang, Tiancong Ma, Yinuo Zhang, Jian Yu, Zhenming Zhang, Zhaolin Teng, Maimaitirexiati Helili, Shengxuan Cao, Xiang Geng and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jinyang LyuDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.
Shuaiqi JiangState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, No 1295 Dingxi Road, Shanghai, 200050, China.
Tiancong MaDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.
Yinuo ZhangDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.
Jian YuDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.
Zhenming ZhangDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.
Zhaolin TengDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.
Maimaitirexiati HeliliDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.
Shengxuan CaoDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.
Xiang GengDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.
Xu WangDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.
Jia JiangDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.
Jiajun QiuState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, No 1295 Dingxi Road, Shanghai, 200050, China.
Xin SunDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China.
Xuanyong LiuState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, No 1295 Dingxi Road, Shanghai, 200050, China.
Xin MaDepartment of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Shanghai, 200040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Absorbable implants such as polylactic acid (PLA), which obviate the need for secondary removal surgery and avoid stress shielding, have emerged as promising alternative internal fixation systems compared to conventional metallic implants. However, some issues hinder their widespread applications including implant-related infection, subsequent poor osseointegration and poor radiopacity, potentially resulting in implant failure or related complications, particularly in the osteoporotic patients. Herein, we constructed a multilayer coating by radiofrequency magnetron sputtering technologies to modify the PLA surface with magnesium oxide (MgO) in the outer layer, cerium dioxide (CeO

Indexed as

Anti-infectionCerium dioxideMagnesium oxideOsseointegrationPolylactic acid

Identifiers

PMID41716352
PMCPMC12915288

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.