ArticleMaterials today. Bio2026
One-step green assembly of natural polyphenol-based nobiletin nanoparticles for ulcerative colitis therapy.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Carrier-free self-assembled nanoparticles derived from traditional Chinese medicine active components: construction strategies and applications.RSC advances · 2026Review
- Versatile metal-phenolic network structure (MPNs) as advanced delivery platforms for bioactive compounds: The design principles, foundations, applications, and future perspectives.Materials today. Bio · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Function-inspired design of natural building blocks enables engineering nanostructured particles for tailored applications. Here, a facile coordination-driven assembly of natural polyphenols was proposed for incorporating hydrophobic citrus-derived nobiletin (NOB) into the nanoparticles (NPs) via a one-pot method in aqueous solutions. The obtained NPs provide high NOB encapsulation efficiency with small, but uniform size (≈250 nm). Moreover, they possessed prolonged colloidal stability and excellent biocompatibility and achieved robust therapeutic efficacy in alleviating ulcerative colitis (UC), in comparison with free NOB. Mechanistically, the desirable NPs maximized the inherent anti-inflammatory and antioxidant activities of natural building blocks, enabling effective attenuation of intestinal inflammation and oxidative stress, thus contributing to the restoration of the intestinal mucosal barrier and immune homeostasis. Overall, this work proposes a promising self-assembly strategy to improve the bioavailability and therapeutic potential of natural flavonoids for the treatment of UC, and ultimately offering potential benefits for patients suffering from it.
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