Evidence map›Paper›PMID 41716338›Full record

ArticleMaterials today. Bio2026

ROS-responsive, brain- and M1 microglia-targeting modified ginkgetin-loaded smart liposomes ameliorate cerebral ischemia by HIF-1α-mediated negative regulation of microglia pyroptosis.

Xueyuan Li, Zi Ye, Wenyang Nie, Bao Zhou, Haocheng Qin, Zhijie Zhao, Yilong Fu, Dun Liu, Shaowei Zheng, Liangyu Wang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xueyuan LiDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Zi YeDepartment of Scientific Research, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Wenyang NieCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Bao ZhouDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Haocheng QinDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Zhijie ZhaoDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yilong FuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Dun LiuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Shaowei ZhengDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Liangyu WangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Jun MaDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Jingying GuoDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Beibei NieDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Yan LuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Dongming YanDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Zhiwen LuoDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Qingshan WangDepartment of Vascular Surgery, The First Affiliated Hospital of Guangzhou Medical University Guangzhou, Guangdong 510120, China.
Meng BianDepartment of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Hui JiangDepartment of Orthopedics, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, 210000, China.
Di ChenDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, 450052, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke triggers a cascade of mitochondrial dysfunction, oxidative stress, neuroinflammation, and pyroptosis, ultimately leading to neuronal injury and neurological deficits. Therapeutic efficacy is often limited by inadequate blood-brain barrier penetration and off-target effects. To address these challenges, we designed 3R@Lipo/Gink, a biocompatible liposomal formulation modified with an ROS-responsive TK polymer and two functional peptides-RVG29 for enhanced brain delivery and MG1 for microglia enrichment-to enable precise transport of ginkgetin, which has been demonstrated to exert neuroprotective effects through multiple potential mechanisms, to ischemic lesions. In a middle cerebral artery occlusion/reperfusion model, 3R@Lipo/Gink markedly reduced infarct size, alleviated neuronal injury, and improved motor performance. Single-cell RNA sequencing and

Indexed as

Brain-targeted drug delivery systemGinkgetinHIF-1αIschemia strokeMicrogliaOxidative stressPyroptosis

Identifiers

PMID41716338
PMCPMC12915267

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.