Evidence map›Paper›PMID 41716315›Full record

ArticleFrontiers in pharmacology2026

Association of serum methylglyoxal with endothelial dysfunction in patients with type 2 diabetes.

Shanshan Yu, Xinyan Jin, Yuanying Xu, Zhao Liu, Jun Lu, Jie Gao, Wenjun Sha, Tao Lei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shanshan Yu *Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xinyan Jin *Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yuanying XuDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhao LiuDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jun LuDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jie GaoDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wenjun ShaDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Tao LeiDepartment of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To explore the correlation between serum Methylglyoxal (MGO) and endothelial dysfunction in patients with type 2 diabetes mellitus, and to evaluate the clinical value of MGO in the development of diabetes mellitus and its complications. Methods: In this cross-sectional study, we enrolled 250 patients diagnosed with T2MD. Based on flow-mediated dilation (FMD) measurements, the patients were categorized into normal endothelial function group (FMD ≥6.4%, n = 61) and endothelial dysfunction group (FMD <6.4%, n = 189). Analysis of the relationship between MGO and FMD was conducted via Spearman's correlation, partial correlation, and multiple logistic regression. An ROC curve analysis was utilized to quantify the predictive performance of MGO for endothelial function. Results: Endothelial dysfunction was observed in 189 (76%) patients with type 2 diabetes. Patients with endothelial dysfunction had higher concentration of MGO in the serum (P < 0.001) than those without endothelial dysfunction. Spearman correlation analysis showed that there was a significantly negative correlation between FMD and MGO (R = -0.611, Conclusion: MGO was significantly inversely associated with FMD and endothelial function in T2DM patients, and can be used as a biomarker to assess vascular endothelial health. Detection of serum MGO levels has clinical significance in the prevention of early diabetic vascular disease.

Indexed as

associationbiomarkerdiabetes mellitusendothelial dysfunctionmethylglyoxal

Identifiers

PMID41716315
PMCPMC12913059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.