ArticleFrontiers in microbiology2026
Genome and drug resistance analysis of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Comparative genomics and epidemic success of Mycobacterium tuberculosis lineage 4 in eastern China.BMC genomics · 2026Article
- Article
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10 authors.
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Abstract
Objective: Based on whole-genome sequencing (WGS) technology, the species distribution, genetic correlations, virulence and drug resistance gene characteristics of the clinical isolates of Methods: A total of 113 MABC strains from the Second Affiliated Hospital of Hainan Medical University from 2014 to 2023 were collected. Whole-genome sequencing (WGS) was used for subspecies identification (Average Nucleotide Identity, ANI), genetic distance analysis (single nucleotide polymorphism, SNP), and pan-genome analysis. The distribution of virulence and antibiotic resistance genes was analyzed through the Virulence Factor Database (VFDB) and the Comprehensive Antibiotic Resistance Database (CARD). The drug susceptibility phenotypes were detected by the microbroth dilution method. Results: Among the 113 MABC strains, Conclusion: In Hainan region, environmental exposure is the main source of MABC infection. Whole genome analysis suggests the potential risk of local common exposure. Mma has a better treatment prospect due to its low clindamycin resistance rate. The differentiation of virulence and resistance genes among subtypes provides a molecular basis for the precise prevention and control of MABC infection in tropical regions.
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