Evidence map›Paper›PMID 41716258›Full record

ArticleFrontiers in genetics2026

Analyzing the genetic profile of autistic children and adolescents with minimal verbal abilities.

Silvia Guerrera, Ilaria Venezia, Maria Grazia Logrieco, Laura Casula, Rossella Capolino, Maria Cristina Digilio, Maria Lisa Dentici, Marina Macchiaiolo, Federico Casciani, Fabiana Cortellessa and 9 more

Abstract read
In one paragraph

Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Silvia Guerrera *Child Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Ilaria Venezia *Child Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Maria Grazia LogriecoChild Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Laura CasulaChild Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Rossella CapolinoMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Maria Cristina DigilioMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Maria Lisa DenticiMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Marina MacchiaioloMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Federico CascianiMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Fabiana CortellessaMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Lorenzo SinibaldiMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Andrea BartuliMedical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Silvia Di TommasoLaboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Gemma D'EliaLaboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Viola AlesiLaboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Cristina RobertiLaboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Antonio NovelliLaboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Giovanni ValeriChild Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Stefano VicariChild Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Comprehensive care for autistic youth with severe symptoms and language impairment includes genetic testing to find underlying causes. Identifying a genetic diagnosis helps determine prognosis, guide treatment, assess recurrence risk, and connect families with targeted resources and support networks. Methods: This cross-sectional study analyzed retrospectively data of a cohort of 60 Autism Spectrum Disorder Minimally Verbal (MV) past age 5 children and adolescents who underwent several genetic investigations and were included in an evaluation protocol including cognitive, adaptive, psychiatric, parental stress and autism characteristics' evaluations to identify whether there were any specific clinical or genetic characteristics in the group of minimally verbal autistic individuals. Results: The percentage of genetic disorders detected in the series is 22.6%. Two groups of MV autistic individuals were defined: those without a known genetic cause (n = 46, neuropsychological data available for 32 individuals) and those with an associated genetic condition (n = 14, neuropsychological data available for 8 individuals). Most participants in both groups scored below 70 on Nonverbal Intelligence Quotient (NVIQ) (77.5% in the first group Discussion: This is the first study analyzing the genotype-phenotype correlation in MV autistic individuals. In this sample, the prevalence of genetic syndromes was found to be twice as high as in the general autistic population (22.6%

Indexed as

autism spectrum disordergenotype-phenotype correlationsminimally verbalneurodevelopmental disordersyndromes

Identifiers

PMID41716258
PMCPMC12914954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.