Evidence map›Paper›PMID 41716210›Full record

ArticleSurgical case reports2026

Jejunal Metastasis from Malignant Pleural Mesothelioma during Long-Term Nivolumab Therapy: A Case Report and Literature Review.

Hitoshi Minagi, Hideki Aoki, Mikoto Nosaka, Toshihiro Ogawa, Megumi Watanabe, Takashi Arata, Koh Katsuda, Kohji Tanakaya

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Hitoshi MinagiDepartment of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Hideki AokiDepartment of Surgery, National Hospital Organization, Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.
Mikoto NosakaDepartment of Surgery, National Hospital Organization, Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.
Toshihiro OgawaDepartment of Surgery, National Hospital Organization, Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.
Megumi WatanabeDepartment of Surgery, National Hospital Organization, Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.
Takashi ArataDepartment of Surgery, National Hospital Organization, Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.
Koh KatsudaDepartment of Surgery, National Hospital Organization, Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.
Kohji TanakayaDepartment of Surgery, National Hospital Organization, Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGastrointestinal metastasis from malignant pleural mesothelioma (MPM) is exceedingly rare and lacks a standardized diagnostic work-up. CASE PRESENTATION: An 87-year-old man with asbestos exposure and a 5-year history of left-sided MPM, radiographically stable on long-term nivolumab therapy, presented with melena and anemia. Contrast-enhanced CT revealed a circumferential jejunal lesion near the duodenojejunal flexure with enlarged mesenteric nodes. Double-balloon enteroscopy confirmed a 40-mm obstructive tumor, but biopsies were non-diagnostic. Partial jejunectomy with targeted mesenteric lymph-node dissection was performed. Histology with a mesothelioma-oriented immunohistochemical panel-negative for CEA and BerEP4 and positive for broad-spectrum cytokeratins-supported a diagnosis of metastatic MPM; nodal metastases were present. Given his age, no further systemic therapy was administered; the patient died 20 months postoperatively from progression of MPM.

conclusionsIn MPM receiving immune-checkpoint inhibitor therapy, unexplained gastrointestinal bleeding should prompt comprehensive gastrointestinal evaluation, including small-bowel assessment. Surgery can secure symptom relief and a definitive diagnosis.

Indexed as

immune-checkpoint inhibitorsjejunal metastasismalignant pleural mesotheliomasmall-bowel metastasis

Identifiers

PMID41716210
PMCPMC12916218

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