ArticleVeterinary world2025
Acute styrene exposure induces hepatocellular injury and molecular stress responses in
Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background and Aim: Plastic-derived monomers such as styrene are increasingly detected in tropical freshwater ecosystems at concentrations approaching 0.8 mg/L. These contaminants pose toxicological risks to aquatic organisms, particularly through oxidative stress, inflammation, and metabolic disruption. Materials and Methods: Adult Results: Styrene exposure induced concentration-dependent hepatic injury. Histopathological lesions intensified markedly at ≥0.5 mg/L, with prominent vacuolization, necrosis, and inflammatory infiltration. CYP1A1 was strongly upregulated, showing a 36.9-fold increase at 0.75 mg/L (p < 0.01), indicating robust activation of the aryl hydrocarbon receptor (AhR) pathway. Antioxidant enzymes (catalase and SOD) and TNF expression also increased significantly, reflecting oxidative and inflammatory stress. Strong positive correlations (r Conclusion: Acute styrene exposure triggers coordinated hepatocellular injury and molecular stress responses in
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