Evidence map›Paper›PMID 41716028›Full record

ArticleMolecular medicine reports2026

STAT1 accelerates cutaneous melanoma progression through TUBB4A expression regulation.

Rongxin Zhao, Kexin Fang, Xiaofei Zhang, Hongchao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rongxin ZhaoDepartment of Dermatology, Pudong New Area People's Hospital, Shanghai 201200; P.R. China.
Kexin FangDepartment of Dermatology, 921st Hospital of Joint Logistics Support Force People's Liberation Army of China, The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410073, P.R. China.
Xiaofei ZhangShanghai Xinmei Medical Beauty Outpatient Department, Shanghai 200031, P.R. China.
Hongchao LiDepartment of Head and Neck Surgery, The Second Hospital of Zhuzhou City, Zhuzhou, Hunan 412000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present research explored the contributions of signal transducer and activator of transcription 1 (STAT1) and tubulin β4A (TUBB4A) in melanoma pathogenesis, focusing on their roles in modulating cellular proliferation, motility and apoptotic pathways. The goal of the study was to establish foundational evidence of the role of these proteins in melanoma for the development of precision therapeutic interventions. Gene silencing approaches were utilized to suppress STAT1 expression, while TUBB4A overexpression was achieved both

Indexed as

Gene Expression Regulation, NeoplasticMelanomaSkin NeoplasmsSTAT1 Transcription FactorTubulinAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationCutaneous Malignant MelanomaDisease ProgressionHumansMiceSignal TransductionSTAT1 protein, humanSTAT1 Transcription FactorTubulinapoptosiscutaneous melanomamigrationSTAT1TUBB4A

Identifiers

PMID41716028
PMCPMC12930139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.