Evidence map›Paper›PMID 41715947›Full record

ArticleAnimal biotechnology2026

Transcriptomic regulation of the hypothalamic-pituitary axis by GnRH immunization in Xizang sheep.

Tianzeng Song, Shehr Bano Mustafa, Haiyan Li, Xiaoming Zhang, Gaofu Wang, Tingting Zhang, Xiaoying Chen, Jianzhao Cui, Ming Zhang, Xianyin Zeng and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tianzeng SongCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.
Shehr Bano MustafaCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China.
Haiyan LiCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China.
Xiaoming ZhangCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China.
Gaofu WangChongqing Academy of Animal Sciences, Rongchang, China.
Tingting ZhangCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China.
Xiaoying ChenInstitute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.
Jianzhao CuiShigatse Science and Technology Bureau, Shigatse, China.
Ming ZhangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Xianyin ZengCollege of Life Science, Sichuan Agricultural University, Ya'an, China.
Guiqiong LiuCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-3688-5958
Lili XianInstitute of Animal Science, Xizang Academy of Agricultural and Animal Husbandry Science, Lhasa, Xizang, China.
Zhuoma JiayangShigatse Agricultural and Animal Husbandry Science Research and Promotion Center, Shigatse, China.
Wangsheng ZhaoCollege of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China.
Xunping JiangCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-7822-1784

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xizang sheep are vital economic livestock in plateau regions. Traditional surgical castration often induces stress and infection. Although immunization presents an alternative method, the physiological mechanisms underlying its effects in Xizang sheep remain unclear. Therefore, this study integrated serum immune-antioxidant indicators with hypothalamus-pituitary transcriptomics to investigate molecular mechanisms of GnRH immunization. Results indicated that serum IgA, IgG, IgM, SOD, and GSH in the immunization (IM) group were significantly higher than in control (CON) and surgical castration (SN) groups, while IL-6 and TNF-α were significantly reduced (

Indexed as

Gonadotropin-Releasing HormoneHypothalamo-Hypophyseal SystemImmunizationTranscriptomeAnimalsGene Expression RegulationHypothalamic-Pituitary-Gonadal AxisMalePituitary GlandSheepGonadotropin-Releasing HormoneHypothalamusMale Xizang sheepPituitary glandTranscriptome sequence

Identifiers

PMID41715947
PMCPMC12927403

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.