Evidence map›Paper›PMID 41715885›Full record

ArticleBiomarkers in medicine2026

Novel circRNA signatures in cervical cancer: implications for early detection and screening.

Michael Zhong, Josephine Peitz, Michelle Newman, Samiatu Yussuf, Clement A Adebamowo, Kiranpreet K Chawla, Diana N Carvajal, Amy J Plotkin, Paul N Staats, Sally N Adebamowo

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Article in Biomarkers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael ZhongDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Josephine PeitzDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Michelle NewmanDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Samiatu YussufDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Clement A AdebamowoDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Kiranpreet K ChawlaDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Diana N CarvajalDepartment of Family Medicine and Community Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Amy J PlotkinDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Paul N StaatsDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Sally N AdebamowoDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCircular RNAs (circRNAs) are emerging as potential biomarkers due to their role in gene regulation. We explored whether specific circRNAs could serve as biomarkers for cervical cancer screening by distinguishing between different stages of cervical disease. AREAS COVERED: We analyzed circRNA expression from archival formalin-fixed paraffin-embedded cervical tissues obtained from 272 women, of which 36% were benign, 33% were precancerous and 31% were cancerous. We performed differential expression analysis using DESeq2 to identify circRNAs that showed log2 fold change ≥2. EXPERT OPINION/COMMENTARY: We identified 5790 statistically significant circRNAs that were differentially expressed between benign and cancerous cervical tissues; circ_0123115 (log2FC = 5.10,

Indexed as

Biomarkers, TumorEarly Detection of CancerRNA, CircularUterine Cervical NeoplasmsAdultFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMiddle AgedBiomarkers, TumorRNA, Circularcancer geneticscancer screeningcervical cancerCircular RNAs (circRNAs)differential expression analysis

Identifiers

PMID41715885
PMCPMC12947582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.