Evidence map›Paper›PMID 41715297›Full record

ArticleExpert review of clinical pharmacology2026

Could GUCY2C-targeted pharmacotherapy be effective in treating colorectal cancer?

Scott A Waldman, Adam E Snook

Abstract readEditorial
In one paragraph

Article in Expert review of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Scott A WaldmanDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Adam E SnookDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9216-4560

Funding

Targeting visceral pain through intestinal neuropod cell GUCY2C signalingR01DK138834 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI MANUEL L COVARRUBIAS, Scott A. Waldman · 2023 to 2026
$3.4M
Neuroprotection by the GUCY2C gut-brain axis in Parkinson's diseaseR21NS130388 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2023 to 2023
$429k
NIDDK NIH HHS R01 DK138834NINDS NIH HHS R21 NS130388
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cGMPcolorectal cancerGUCY2Cimmunotherapy

Identifiers

PMID41715297
PMCPMC13316204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.