Evidence map›Paper›PMID 41715277›Full record

SynthesisChildhood obesity (Print)2026

The Effect of GLP-1 Receptor Agonists on Alanine Aminotransferase and Other Metabolic Parameters in Youths with Obesity: A Systematic Review and Meta-Analysis.

Lauren A Hertzer, Robert M Siegel, Roohi Y Kharofa, Kristin M Stackpole, E Melinda Mahabee-Gittens

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Childhood obesity (Print), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren A HertzerUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Robert M SiegelUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Roohi Y KharofaUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Kristin M StackpoleUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
E Melinda Mahabee-GittensUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-3893-885X

Funding

Prevalence and Clinical Correlates of Thirdhand Smoke Exposure in a Pediatric Patient PopulationR01ES030743 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI MAHABEE-GITTENS, E. MELINDA · 2019 to 2023
$2.9M
NIEHS NIH HHS R01 ES030743
6 · The paper itself

Abstract

backgroundWhile glucagon-like peptide-1 receptor agonists (GLP-1 RAs) lower body mass index (BMI) in youths with obesity, less is known about their effect on metabolic parameters such as alanine aminotransferase (ALT), high-density lipoprotein, low-density lipoprotein, and hemoglobin A1c levels. We conducted a systematic review of the existing literature and a meta-analysis to determine the effect of GLP-1 RAs on metabolic parameters.

methodsA search of the PubMed, Scopus, and Embase databases was conducted with variations of the terms GLP-1, obesity, semaglutide, exenatide, liraglutide, randomized clinical trial, adolescent, youth, and children.

resultsA total of 197 studies were identified, of which 6 satisfied the inclusion criteria. Four studies focused on exenatide, one on semaglutide, and one on liraglutide, with participant numbers ranging from 11 to 201 and study lengths of 12 to 68 weeks. Only BMI (-1.7,

conclusionsOur meta-analysis suggests GLP-1 RAs improve BMI and show a modest decrease in ALT levels in youths with obesity. The clinical significance of the ALT decreases remains uncertain and warrants further examination in future trials.

Indexed as

Alanine TransaminaseGlucagon-Like Peptide-1 Receptor AgonistsPediatric ObesityAdolescentBody Mass IndexChildExenatideGlucagon-Like PeptidesGlycated HemoglobinHumansHypoglycemic AgentsLiraglutideSemaglutideAlanine TransaminaseExenatideGlucagon-Like Peptide-1 Receptor AgonistsGlucagon-Like PeptidesGlycated HemoglobinHypoglycemic AgentsLiraglutideSemaglutidealanine aminotransferasemeta-analysisobesityyouths

Identifiers

PMID41715277
PMCPMC13191177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.