ArticleBiological research2026
The polyamine inhibitor SAM486A increases the efficacy of adagrasib in non-small cell lung cancer cells harboring KRAS
Article in Biological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNon-small cell lung cancer (NSCLC) accounts for most lung cancer cases and poses major challenges due to late-stage diagnosis and limited options. A substantial subset of NSCLC harbors KRAS mutations, most commonly at codon 12. Although KRAS
methodsIn vitro assays included viability (MTT), clonogenic, BrdU incorporation, and Western blot analyses across four NSCLC cell lines. Drug-drug interactions were quantified using Combenefit software. In vivo efficacy was tested in C57BL/6 mice using an orthotopic model with LLC46 (KRAS
resultsIn vitro, adagrasib reduced AMD1 levels, and SAM486A synergistically enhanced its antiproliferative effects, particularly in KRAS
conclusionsOur results suggest that targeting polyamine metabolism with SAM486A enhances the efficacy of KRAS
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