Evidence map›Paper›PMID 41715230›Full record

ArticleBioelectronic medicine2026

Exploring vagus nerve stimulation in postoperative delirium and dementia.

Rachel M Spicer, Peder S Olofsson, Fiona E Harrison

Abstract readLetter
In one paragraph

Article in Bioelectronic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rachel M SpicerDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.
Peder S OlofssonDepartment of Medicine, Laboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Fiona E HarrisonDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA. Fiona.harrison@vumc.org.

Funding

Neuroinflammatory mechanisms underlying sepsis-induced cognitive dysfunctionRF1AG075341 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, JULIE A., HARRISON, FIONA EDITH · 2022 to 2025
$3.3M
NIA NIH HHS AG075341NIA NIH HHS RF1 AG075341
6 · The paper itself

Abstract

Microglial activation and neuroinflammation, important aspects of neurodegeneration and accumulation of amyloid-pathology, is often exacerbated by peripheral inflammation following surgical procedures. Subsequent postoperative delirium is a predictor for long-term cognitive decline and increased rick of Alzheimer’s Disease, and perioperative strategies to reduce inflammatory responses, may be a potential avenue to mitigate postoperative complications. In this issue of Bioelectronic Medicine, Song et al. utilize percutaneous vagus nerve stimulation (pVNS) as a potential novel avenue for the attenuation of neuroinflammation and postoperative cognitive decline, which we have discussed in this commentary.

Indexed as

Alzheimer’s DiseaseDeliriumDelirium superimposed on DementiaMicrogliaNeuroinflammationVagus Nerve Stimulation

Identifiers

PMID41715230
PMCPMC12922289

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.