Evidence map›Paper›PMID 41715158›Full record

ReviewInfectious agents and cancer2026

Digital health technologies in medicine: evidence, artificial intelligence integration, and ethical challenges.

Marco Cascella, Cesare Pane, Marcello Di Pumpo, Enrico Sebastiani, Martino Bussa, Alessio Tagliaferri, Barbara Brunetti, Pierluigi Meloni, Elisa Bianchini, Paolo Graziani and 11 more

Abstract readReview
In one paragraph

Review in Infectious agents and cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marco CascellaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081, Baronissi, Salerno, Italy.
Cesare PaneDepartment of Medicine and Ageing Sciences, Center for Advanced Studies and Technology CAST. "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy.
Marcello Di PumpoDepartment of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 20123, Rome, Italy.
Enrico SebastianiNeuromuscular and Rare Disorders Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, NICU, via Commenda 12, 20122, Milan, Italy.
Martino BussaSchool of Medicine and Surgery, University of Milano-Bicocca, 20126, Milan, Italy.
Alessio TagliaferriIndependent Researcher, Naples, Italy.
Barbara BrunettiDepartment of Veterinary Medical Sciences, University of Bologna, 40064, Bologna, Italy.
Pierluigi MeloniDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Elisa BianchiniIndependent Researcher, Naples, Italy.
Paolo GrazianiIndependent Researcher, Naples, Italy.
Federico FaustiniIndependent Researcher, Naples, Italy.
Guido D'OnofrioAzienda Sanitaria Locale di Pescara, Via Renato Paolini 47, 65124, Pescara, Italy.
David ManettaIndependent Researcher, Naples, Italy.
Cristina Angela CataniaSynbrAIn., Milan , Italy.
Chiara Jole FornariIndependent Researcher, Naples, Italy.
Andrea ScardaIndependent Researcher, Rome, Italy.
Federica SmanioIndependent Researcher, Naples, Italy.
Cristina ImbesiIndependent Researcher, Naples, Italy.
Maria Teresa AvellaIstituto Nazionale Previdenza Sociale, Centro Medico Legale di Lucca, Via Barsanti e Matteucci 173, 55100, Lucca, Italy.
Roberta FuscoRadiology Division, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Via Semmola, 80131, Naples, Italy. r.fusco@istitutotumori.na.it.
Vincenza GranataRadiology Division, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Via Semmola, 80131, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Digital health technologies (DHTs), including digital therapeutics (DTx), are revolutionizing patient care by enabling the prevention, management, and treatment of medical conditions. These tools comprise care delivery mobile applications, wearable devices, and cloud platforms for capturing real-time data and enabling remote monitoring. DTx are regulated, software-based interventions that deliver evidence-supported therapeutic effects; artificial intelligence (AI) and machine learning, including advanced architectures, such as agentic systems and digital twins, may augment DTx workflows but are not defining features of DTx. Growing evidence supports the effectiveness of DHT strategies across different clinical fields. For example, wearable and remote patient monitoring technologies enable continuous assessment and personalized feedback in cardiology and neurology. Additionally, AI-enabled devices are widely implemented for continuous monitoring of glucose levels. However, several key challenges remain. Persistent gender and social biases in datasets and algorithms raise ethical concerns, particularly for underrepresented groups and pediatric populations. Mitigation strategies include regulatory frameworks, explainable AI, and trustworthy AI ecosystems. This work is a narrative, expert-driven review based on illustrative literature curated by domain specialists. It aims to synthesize current evidence, highlight implementation barriers, and propose recommendations to enhance inclusivity, interoperability, and real-world evaluation of digital health technologies. Applications of DHTs in animals within a One Digital Health framework, as well as potential applications in infection-related oncology, are also discussed.

Indexed as

Artificial intelligenceDigital healthDigital therapeuticsEthicsHealthcareRemote patient monitoringVeterinaryWearables

Identifiers

PMID41715158
PMCPMC12990400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.