ArticleJournal of nanobiotechnology2026
Poly-l-lactic acid electrospun membrane with specific morphology promotes bone regeneration through macrophage reprogramming.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Sequential polarization of macrophages: an immunomodulatory strategy for novel bone repair materials.Regenerative biomaterials · 2026Review
- Multimodal data integration in orthopedic regenerative medicine: bridging imaging, omics, and clinical data.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Host immune response to bone biomaterials plays a crucial role in influencing the outcome of bone regeneration. In this research, electrospun membranes composed of poly-l-lactic acid (PLLA) with different configurations (aligned and random) and sizes (nanoscale and microscale) were created, and the molecular mechanisms through which PLLA electrospun membranes facilitate bone regeneration were investigated. Firstly, when various material groups were inserted into the rat skull defect model, the bone defect repair was most obvious in the aligned 600 nm group compared with other groups. Then, single-cell RNA sequencing was performed on the bone tissues of the aligned 600 nm group to analyze the characteristics of the immune microenvironment, and the results showed that the effect of PLLA electrospinning membrane on bone regeneration was closely related to the transformation of macrophage subtypes. Finally, the co-culture of macrophages and bone mesenchymal stem cells identified that the molecular pathway involving "PLLA electrospun membrane-M2 macrophage polarization-osteogenic differentiation" could serve as a potential mechanism for bone regeneration. Collectively, the PLLA electrospun membrane with specific morphology promotes bone regeneration by macrophage reprogramming. These findings offer significant insights for the advancement of biomimetic materials aimed at tissue regeneration from the viewpoint of osteo-immunomodulation.
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Registered trials
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