ArticleBMC infectious diseases2026
Early signaling of inflammatory bursts by using estimated C-reactive Protein velocity (eCRPv): a model of acute meningitis and iso-CRPinemia.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeC-Reactive Protein (CRP) is often used to support the differentiation between acute bacterial and viral infections, including acute meningitis. However, this is not always possible due to similar CRP concentrations upon presentation in these two cohorts. We have improved the diagnostic yield of this biomarker by adjusting its concentrations to the estimated time from disease onset, transforming a single, static value into a dynamic measurement, expressed in milligrams per liter per hour.
methodsOur study included 46 matched pairs of patients with acute bacterial and acute viral meningitis who were presented to the hospital with similar CRP concentrations (± 10%). Estimated CRP velocity (eCRPv) was calculated by dividing the first CRP measurement at the Emergency department (ED) by the estimated time of disease onset (iso-CRPinemic model).
resultsThere was negligible difference (p = 0.4) between the mean ± s.d. CRP concentrations in the bacterial (110.1 ± 66.9 mg/L) versus the viral (110.0 ± 68.4 mg/L) group. However, when we adjusted these concentrations to the time from onset of the clinical picture of acute meningitis, it served to differentiate well (p < 0.001) between the groups.
conclusionThe diagnostic yield of CRP at presentation amongst patients with acute meningitis can be improved by adjusting the value to the estimated time from disease onset.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.