ArticleBMC neurology2026
A case report of neurosarcoidosis mimicking Guillain-Barré syndrome: the diagnostic utility of skin biopsy in neurosarcoidosis.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWe report a compelling case of neurosarcoidosis in a 74-year-old Japanese woman. She initially presented with a clinical course that closely mimicked Guillain-Barré syndrome (GBS), and the definitive diagnosis of neurosarcoidosis was eventually made through a skin biopsy. CASE PRESENTATION: The patient presented with progressive limb weakness and sensory disturbances and was initially treated for a presumptive diagnosis of GBS. Although her condition showed an initial temporary improvement, her symptoms subsequently relapsed and worsened. This atypical and relapsing clinical pattern prompted a comprehensive systemic workup to find an alternative diagnosis. Based on the histological findings on skin biopsy and the clinical presentation, a diagnosis of probable neurosarcoidosis was made.
conclusionThis case highlights the importance of considering neurosarcoidosis in the differential diagnosis of GBS with an atypical course. A comprehensive systemic workup is crucial for such cases. It further emphasizes that a thorough systemic evaluation is essential for accurate diagnosis, as a simple and accessible procedure like a skin biopsy can provide essential histological evidence to support the diagnosis.
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