ArticleBMC infectious diseases2026
Association of De Ritis ratio with mortality in ICU patients with sepsis-associated acute kidney injury: a retrospective multicenter cohort study.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSepsis-associated acute kidney injury (SA-AKI) is associated with adverse clinical outcomes. The De Ritis ratio (AST/ALT) has been studied as a biomarker for various diseases; however, its relationship with mortality in intensive care unit (ICU) patients with SA-AKI remains unclear.
methodsThis multicenter retrospective cohort study used data from Medical Information Mart for Intensive Care IV (MIMIC-IV) database and eICU Collaborative Research Database (eICU-CRD). The Boruta algorithm, Kaplan-Meier method, and Cox proportional hazards model was used for the analysis.
resultsA total of 24,468 patients were included. The De Ritis ratio was significantly higher in deceased patients. The Boruta algorithm identifies it as an important predictor of mortality. Kaplan-Meier analysis showed higher mortality in the groups with elevated De Ritis ratios. Cox analysis indicated that it was a significant risk factor for mortality, with nonlinear associations found using RCS.
conclusionThe De Ritis ratio is a significant and independent predictor of mortality in ICU patients with SA-AKI, highlighting its potential clinical utility in assessing prognosis and aiding in treatment decisions. Further prospective studies are required to confirm these findings.
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