Evidence map›Paper›PMID 41714931›Full record

Observational studyBMC emergency medicine2026

Patterns and determinants of medication use by paramedics in German prehospital emergency care: a six-year multicenter analysis.

Christian Hohenstein, Steffen Wolfgang Nix

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christian HohensteinFaculty of Medicine, Phillips-University Marburg, Baldinger Str. 1, 35037, Marburg, Germany. christianhohenstein@icloud.com.ORCID 0000-0001-5420-6512
Steffen Wolfgang NixFaculty of Medicine, Phillips-University Marburg, Baldinger Str. 1, 35037, Marburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMedication administration is a fundamental component of paramedic-provided prehospital emergency care within a physician-based EMS-System. In Germany, the Emergency Paramedic Act expanded pharmacological competencies and authorization pathways, yet real-world utilization of medications in routine EMS practice remains insufficiently described. This study aimed to quantify medication use, characterize medication categories and administration routes, and assess temporal and regional variation across three German EMS districts.

methodsWe conducted a retrospective multicenter observational study of all paramedic-led EMS missions without on-scene physician involvement between 1 January 2019 and 31 December 2024. Electronic patient care records from three mixed urban–rural EMS districts were analyzed. Outcomes included the proportion of missions with medication administration, distribution of medication classes, administration routes, six-year temporal trends, and interregional differences. Statistical analyses included descriptive measures, chi-square tests, and Cochran–Armitage trend testing.

resultsAmong 197,432 eligible missions, 22,340 involved medication administration (11.3%). Crystalloids (4.1%) and analgesics (3.2%) were the most frequently administered medications, followed by bronchodilators (1.4%), glucose (1.2%), and antiemetics (0.5%). Advanced medications were used in 0.9% of missions. Medication administration increased significantly from 9.4% in 2019 to 12.1% in 2024 (p = 0.02). Intravenous administration was predominant (76.3%). Districts with telemedical physician support demonstrated higher overall medication use compared to the district without tele-EMS (12.7% vs. 9.1%; p < 0.001).

conclusionsMedication use in German paramedic-led prehospital care remains concentrated on a narrow spectrum of frequently used medication categories despite expanded legal competencies and a comprehensive pharmacology curriculum. A system supervised by the EMS medical director (ÄLRD) is essential to ensure patient safety and to support the maintenance of pharmacological competencies.

Indexed as

Emergency Medical ServicesGermanyHumansParamedicineParamedicsRetrospective StudiesDrug administration routesEmergency medical techniciansEmergency medicine servicesGeographic variationPharmaceutical preparationsTelemedicine

Identifiers

PMID41714931
PMCPMC12930623

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.