Evidence map›Paper›PMID 41714915›Full record

ReviewCurrent organic synthesis2025

Recent Advances in the Synthesis and Biological Activities of Quinolactacin and its Derivatives: A Comprehensive Review.

Noor Hidayah Pungot, Siti Wadhihah Athirah Ab Rahman, Nuriyah Izzati Syafawi, Putri Nur Arina Mohd Ariff, Siti Zafirah Binti Zulkifli, Aimi Suhaily Saaidin

Abstract readReview
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In one paragraph

Review in Current organic synthesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Noor Hidayah PungotOrganic Synthesis Laboratory, Institute of Science, Level 9, FSK 2,3,4 Building, Universiti Teknologi MARA, Cawangan Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.ORCID 0000-0003-0322-263X
Siti Wadhihah Athirah Ab RahmanFaculty of Pharmacy, Universiti Teknologi MARA, Cawangan Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
Nuriyah Izzati SyafawiOrganic Synthesis Laboratory, Institute of Science, Level 9, FSK 2,3,4 Building, Universiti Teknologi MARA, Cawangan Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
Putri Nur Arina Mohd AriffOrganic Synthesis Laboratory, Institute of Science, Level 9, FSK 2,3,4 Building, Universiti Teknologi MARA, Cawangan Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
Siti Zafirah Binti ZulkifliOrganic Synthesis Laboratory, Institute of Science, Level 9, FSK 2,3,4 Building, Universiti Teknologi MARA, Cawangan Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.ORCID 0000-0003-2530-8194
Aimi Suhaily SaaidinOrganic Synthesis Laboratory, Institute of Science, Level 9, FSK 2,3,4 Building, Universiti Teknologi MARA, Cawangan Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.ORCID 0000-0002-7968-6169

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, quinolactacins and their derivatives have attracted significant research attention due to their distinctive structural features and intriguing biological properties. These heterocyclic compounds have emerged as promising candidates in medicinal chemistry due to their broad spectrum of therapeutic activities. This review article provides a comprehensive study on recent progress in synthesising and investigating the biological properties of quinolactacins and their diverse analogues, offering insights into the diverse synthetic strategies that have been explored to enhance the efficiency and scalability of their production. The primary emphasis lies on the biological activities exhibited by quinolactacins, including their notable anti-bacterial efficacies, anti-cancer, anti-proliferative, anti-oxidant, anti-malarial, and anti-viral. These compounds have shown great potential as therapeutic agents in the fight against various infectious diseases and cancers, making them promising candidates for drug development. Moreover, this study sheds light on the latest endeavours aimed for the synthesis of quinolactacins and their derivatives. This study serves as a valuable resource for researchers who aim to investigate and further harness the therapeutic potential of quinolactacins and their derivatives in the battle against life-threatening diseases, paving the way for future breakthroughs in drug development.

Indexed as

Antineoplastic AgentsLactonesAnimalsAnti-Bacterial AgentsAnti-Infective AgentsAntimalarialsAntioxidantsAntiviral AgentsHumansAnti-Bacterial AgentsAnti-Infective AgentsAntimalarialsAntineoplastic AgentsAntioxidantsAntiviral AgentsLactonesanti-bacterialanti-canceranti-viralBiological activitiesheterocyclic compounds.quinolactacinsynthesis route

Identifiers

PMID41714915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.