Evidence map›Paper›PMID 41714737›Full record

ArticleNature immunology2026

Phosphorylation of Runx protein controls helper CD4

Chihiro Ogawa, Kazuki Okuyama, Satoshi Kojo, Kohei Nishino, Hiroaki Machiyama, Aditya K Padhi, Hirotaka Takahashi, Takashi Ebihara, Mari Tenno, Qin Zhizhen and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chihiro Ogawa *Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0009-0008-6915-0062
Kazuki Okuyama *Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-0262-9326
Satoshi Kojo *Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-9263-8831
Kohei NishinoDivision of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Hiroaki MachiyamaDepartment of Immunology, Tokyo Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5524-581X
Aditya K PadhiLaboratory for Structural Bioinformatics, RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0001-6732-2547
Hirotaka TakahashiDivision of Cell-Free Science, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan.
Takashi EbiharaLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-6056-3230
Mari TennoLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.
Qin ZhizhenLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.
Sawako MuroiLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.
Kosei ItoDepartment of Molecular Tumor Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Tatsuya SawasakiDivision of Cell-Free Science, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan.
Kam Y J ZhangLaboratory for Structural Bioinformatics, RIKEN Center for Biosystems Dynamics Research, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-9282-8045
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.ORCID http://orcid.org/0000-0002-9163-7669
Tadashi YokosukaDepartment of Immunology, Tokyo Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3914-3995
Hidetaka KosakoDivision of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID http://orcid.org/0000-0003-3228-6368
Ichiro TaniuchiLaboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan. ichiro.taniuchi@riken.jp.ORCID http://orcid.org/0000-0002-7783-7226

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MHC-I- and MHC-II-selected CD4

Indexed as

CD8-Positive T-LymphocytesCore Binding Factor Alpha 2 SubunitT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerAnimalsCell DifferentiationCell LineageLymphocyte Specific Protein Tyrosine Kinase p56(lck)MiceMice, Inbred C57BLPhosphorylationReceptors, Antigen, T-CellSignal TransductionThymocytesTranscription FactorsZAP-70 Protein-Tyrosine KinaseCore Binding Factor Alpha 2 SubunitLymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-CellRunx1 protein, mouseTranscription FactorsZap70 protein, mouseZAP-70 Protein-Tyrosine KinaseZbtb7b protein, mouse

Identifiers

PMID41714737
PMCPMC13043292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.