ArticlePediatric research2026
Early developmental intervention and neurodevelopmental trajectories in preterm infants without severe brain injury.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
backgroundEarly developmental intervention seeks to enhance functional outcomes in preterm infants by leveraging neuroplasticity. We investigated the relationship between early intervention and neurodevelopmental outcomes in early childhood among preterm infants without severe brain injury.
methodsThis prospective cohort study enrolled very-low-birth-weight infants (23
resultsOf the 1797 infants who completed follow-up, 518 (28.8%) received early intervention. Compared to infants without early intervention, those with early intervention had lower gestational age and higher rates of prematurity-related complications and post-discharge rehospitalizations. The interaction between the intervention group and assessment time was statistically significant, indicating that early intervention was associated with a reduced risk of motor developmental delays over time (adjusted odds ratio 0.669, 95% confidence interval 0.472-0.949).
conclusionEarly intervention was associated with more favorable motor outcomes, highlighting the importance of timely support for high-risk preterm infants. IMPACT: Preterm infants with greater medical complexity more commonly received early intervention. Early intervention mitigated the progression of motor developmental delays over time. An enriched early environment may help offset the negative developmental impact of preterm complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.