Evidence map›Paper›PMID 41714566›Full record

ReviewIntensive care medicine experimental2026

Current rat models of extracorporeal life support following global ischaemia: a scoping review.

Johannes Dinkelaker, Jan-Steffen Pooth, Georg Trummer, Sonja Bröer, Hans-Jörg Busch, Marius Schimmel, Jakob Wollborn, Sam Joé Brixius

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Johannes DinkelakerCenter for Experimental Models and Transgenic Service CEMT-FR, Medical Center, Faculty of Medicine, University of Freiburg, Breisacher Str. 66, 79106, Freiburg, Germany. johannes.dinkelaker.cemt@uniklinik-freiburg.de.ORCID http://orcid.org/0009-0004-4653-1293
Jan-Steffen PoothDepartment of Emergency Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Georg TrummerDepartment of Emergency Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Sonja BröerInstitute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Hans-Jörg BuschDepartment of Emergency Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Marius SchimmelDepartment of Cardiovascular Surgery, Faculty of Medicine, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Jakob WollbornDepartment of Anesthesiology, Mass General Brigham, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Sam Joé BrixiusDepartment of Emergency Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSmall animal models are indispensable in cardiovascular research. This scoping review aims to provide an overview of contemporary rat models for extracorporeal life support (ECLS) after global ischaemia. MATERIAL AND

methodsA systematic search was conducted in PubMed, Web of Science and Embase to identify studies involving rat models of global ischaemia followed by ECLS from January 2000 to December 2024. Title and abstracts were screened by two independent reviewers, and the remaining full text was included in predefined data extraction forms.

resultsA total of 79 studies met the inclusion criteria. Male Sprague Dawley rats were predominantly used (82%), with limited reporting on animal age and inconsistent use of analgesia. The majority of studies employed ECLS configurations with roller pumps (71%), custom-made oxygenators (41%), venous drainage via the jugular vein (96%) and arterial inflow via the femoral (53%) or caudal (35%) artery. Three distinct clinical scenarios were identified: extracorporeal cardiopulmonary resuscitation (41%), emergency preservation and resuscitation (13%), and deep hypothermic circulatory arrest (47%). Substantial methodological heterogeneity was observed across models, particularly in ischaemia induction, ECLS protocols, outcome measures, and reporting standards.

conclusionRat models are increasingly used in ECLS research and offer valuable opportunities for investigating pathophysiological mechanisms and advantages for translational studies. To utilize their full potential, improved standardization and adherence to existing guidelines are needed to enhance their reproducibility and clinical relevance.

Indexed as

Acute care medicineCardiac arrestCardiopulmonary resuscitationExtracorporeal life supportExtracorporeal resuscitationGlobal ischaemiaRatsReperfusionVentricular fibrillation

Identifiers

PMID41714566
PMCPMC12920849

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.