Evidence map›Paper›PMID 41714564›Full record

ReviewNeuroscience bulletin2026

Kainate Receptors in Sensory Neurons: Molecular Identity and Functional Relevance to Pain.

Sofía Degiorgi, Juan Lerma

Abstract readReview
In one paragraph

Review in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sofía DegiorgiInstituto de Neurociencias, UMH-CSIC, 03550, San Juan de Alicante, Spain.
Juan LermaInstituto de Neurociencias, UMH-CSIC, 03550, San Juan de Alicante, Spain. jlerma@umh.es.ORCID http://orcid.org/0000-0001-7838-5199

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kainate receptors (KARs) are members of the ionotropic glutamate receptor family and possess diverse structural and functional properties that play critical roles in synaptic signaling, plasticity, and neural development. Several KAR subunits are strongly expressed in dorsal root ganglion neurons, and while their involvement in pain has been suggested, their precise role remains unclear. This review re-evaluates the roles of KARs in sensory physiology, with a particular focus on pain mechanisms. By combining recent single-cell transcriptomic data from dorsal root ganglia neurons with experimental evidence on KAR diversity, signaling, and function, we highlight how these receptors may shape sensory processing under normal and pathological conditions.

Indexed as

Ganglia, SpinalKainic Acid ReceptorsPainSensory Receptor CellsAnimalsHumansNociceptionKainic Acid ReceptorsDorsal Root GanglionGRIK1–5Kainate receptorsNociceptionPainTranscriptomics

Identifiers

PMID41714564
PMCPMC13221535

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.