Evidence map›Paper›PMID 41714459›Full record

ReviewImmunologic research2026

The role of metal metabolism in inflammatory bowel disease: Pathogenesis, clinical application, and therapeutic targets.

Huangeng Zhao, Yuchao Sun, Lele Li, Zhenyong Zhang, Xinxin Xu, Dawei Cui, Yingping Wu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huangeng ZhaoDepartment of Clinical Laboratory, the Fourth Affiliated Hospital of School of medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Yuchao SunDepartment of Clinical Research Center, the Fourth Affiliated Hospital of School of medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Lele LiDepartment of Clinical Laboratory, the Fourth Affiliated Hospital of School of medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Zhenyong ZhangDepartment of Clinical Laboratory, the Fourth Affiliated Hospital of School of medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Xinxin XuDongyang Traditional Chinese Medicine Hospital, Dongyang, China.
Dawei CuiDepartment of Blood Transfusion, The First Affiliated Hospital, Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China. daweicui@zju.edu.cn.
Yingping WuDepartment of Clinical Laboratory, the Fourth Affiliated Hospital of School of medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China. yingpingwu@zju.edu.cn.

Funding

Zhejiang Provincial Department of Education Project Y202353450
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) refers to a group of chronic and recurrent inflammatory disorders of the intestine, mainly including ulcerative colitis (UC) and Crohn’s disease (CD). These conditions usually present with abdominal pain, diarrhea, hematochezia, and weight loss, and may also lead to systemic complications. The pathogenesis of IBD is not fully understood but involves complex interactions among genetic predisposition, immune dysregulation, environmental factors, and intestinal microbiota changes. This review summarizes current knowledge of metal metabolism disorders in patients with IBD, with a focus on iron (Fe), copper (Cu), calcium (Ca), magnesium (Mg), zinc (Zn), and manganese (Mn), and their associations with IBD. It also examines the role of metal metabolism disorders in IBD pathogenesis and explores potential therapeutic strategies. Approaches such as inhibition of ferroptosis, regulation of copper homeostasis, modulation of calcium channels, and supplementation with magnesium and zinc, as well as adjustment of manganese metabolism, have been proposed to improve outcomes in IBD. In addition, the review highlights potential therapeutic roles of biological agents and nanomaterials, emphasizing their mechanisms through the regulation of metal metabolism.

Indexed as

Inflammatory Bowel DiseasesMetalsAnimalsCopperHomeostasisHumansCopperMetalsCopper homeostasisFerroptosisGastrointestinal disease treatmentInflammatory bowel diseaseMetal metabolism

Identifiers

PMID41714459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.