Evidence map›Paper›PMID 41714401›Full record

ArticleNature plants2026

A distorter-restorer system drives quantitative reproductive isolation in rice.

Yu Zhang, Ying Yang, Chuanlin Shi, Qiuhong Pu, Jiawu Zhou, Wenchuang He, Peng Xu, Qiang Xu, Fengyi Hu, Xuanchen Song and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yu Zhang *Yunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China. zhangyu_rice@163.com.ORCID http://orcid.org/0000-0003-0921-1755
Ying Yang *Yunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
Chuanlin Shi *State Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0003-4776-1942
Qiuhong PuYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
Jiawu ZhouYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.ORCID http://orcid.org/0000-0002-6000-2994
Wenchuang HeState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0001-5568-7215
Peng XuState Key Laboratory of Plant Diversity and Specialty Crops, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, China.
Qiang XuState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-9307-0504
Fengyi HuInnovation Center of Perennial Rice Technology in Yunnan, New Cornerstone Science Laboratory, School of Agriculture, Yunnan University, Kunming, China.
Xuanchen SongYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.ORCID http://orcid.org/0009-0004-9928-7220
Xiaohan JiangYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
Yonggang LvYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
Liu HeYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.ORCID http://orcid.org/0009-0002-1652-5808
Xianneng DengYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
Lianguang ShangState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. shanglianguang@caas.cn.ORCID http://orcid.org/0000-0002-4606-2800
Dayun TaoYunnan Seed Laboratory, Yunnan Key Laboratory for Rice Genetic Improvement, Food Crops Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China. taody12@aliyun.com.ORCID http://orcid.org/0000-0002-8884-1589

Funding

Applied Basic Research Key Project of Yunnan (Applied Basic Research Key Project of Yunnan Province) 202001AS070003People's Government of Yunnan Province 530000210000000013809People's Government of Yunnan Province YNWR-QNBJ-2018-359
6 · The paper itself

Abstract

Hybrid sterility and segregation distortion are the major forms of postzygotic reproductive isolation in rice, yet the molecular basis of their quantitative variation remains unclear. Here we identify S44, a natural distorter-restorer system in Oryza longistaminata/Asian cultivated rice hybrids, comprising four tightly linked elements-Reproductive Isolation Distorter (RID), Reproductive Isolation Restorer (RIR), Reproductive Isolation Activator (RIA) and Reproductive Isolation Suppressor (RIS)-which collectively regulate hybrid male sterility and segregation distortion. The distorter RID triggers the elimination of O. sativa cultivar RD23 pollen, whereas the restorer RIR selectively safeguards O. longistaminata gametes, thereby preferentially transmitting its allele into the progeny. RIS and RIA fine-tune segregation distortion. We further demonstrate that the allelic conflicts at the S44 locus drive quantitative reproductive isolation between O. longistaminata and other rice lineages, and CRISPR-engineered RID knockout can universally overcome S44-mediated reproductive barriers in the AA genome, enabling revolutionary cross-species breeding. This distorter-restorer system provides a unique genetic module for deciphering speciation mechanisms and advancing crop breeding strategies.

Indexed as

OryzaPlant InfertilityReproductive IsolationHybridization, GeneticPlant Breeding

Identifiers

PMID41714401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.