ArticleInternational journal of obesity (2005)2026
Relationship between the microbiome and obesity-associated cancer risk using Mendelian randomisation.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe mechanisms underlying obesity-related cancer risk are incompletely understood. We investigated whether the gut microbiome causally mediates this relationship.
methodsWe performed two-sample Mendelian randomisation, with mediation analysis, to assess causal links between genetically predicted body mass index (BMI)/waist-to-hip ratio adjusted for BMI (WHRadjBMI), 211 gut microbial taxa, and eight cancers (384,738 cases) of European ancestry. Significant associations were replicated in the FinnGen cohort.
resultsGenetically predicted BMI was associated with risk of colorectal (CRC; odds ratio per standard deviation (OR
conclusionsGut Actinobacteria may contribute to obesity-driven CRC risk, supporting the rationale of microbiome-targeted interventions to reduce CRC risk.
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