Evidence map›Paper›PMID 41714337›Full record

ArticleScientific reports2026

Cocktail of genetically diverse lytic phages reduces uropathogenic Escherichia coli colonization in mouse urinary tract.

Panupon Mongkolkarvin, Chutikarn Sukjoi, Watcharapol Suyapoh, Songphon Buddhasiri, Ifeoluwa Emmanuel Ilugbusi, Poochit Nonejuie, Michael Harrison Hsieh, Vorrapon Chaikeeratisak, Parameth Thiennimitr

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Panupon MongkolkarvinDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Chutikarn SukjoiDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Watcharapol SuyapohDepartment of Veterinary Science, Faculty of Veterinary Science, Prince of Songkhla University, Songkhla, 90110, Thailand.
Songphon BuddhasiriVeterinary Public Health and Food Safety Centre for Asia Pacific, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, 50100, Thailand.
Ifeoluwa Emmanuel IlugbusiDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Poochit NonejuieCenter for Advanced Therapeutics, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
Michael Harrison HsiehDepartment of Microbiology, Immunology, and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, 20052, USA.
Vorrapon ChaikeeratisakDepartment of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Parameth ThiennimitrDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. parameth.t@cmu.ac.th.ORCID http://orcid.org/0000-0002-6339-8744

Funding

Faculty of Medicine, Chiang Mai University MIC-132/2567
6 · The paper itself

Abstract

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common bacterial infections in humans. The rise of multidrug-resistant UPEC strains increases the urgent need for alternative treatment. Two diverse lytic bacteriophages (phages), SR02 and SR04, recently exhibited an in vitro anti-UPEC activity. In this study, we reported the interplay among UPEC, phages, and the microenvironment of mammalian urinary tract in UTI phage therapy using both in vitro (human bladder cell line) and in vivo (murine acute UTI) models. A gentamicin protection invasion assay was performed in UPEC-infected human bladder cells (UM-UC-3). Both monophages and the phage cocktail significantly reduced UPEC invasion into UM-UC-3 with a synergistic effect between SR02 and SR04. Female C57BL/6 mice were transurethrally infected with 10

Indexed as

BacteriophagesEscherichia coli InfectionsPhage TherapyUrinary TractUrinary Tract InfectionsUropathogenic Escherichia coliAnimalsCell LineDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLUrinary BladderBacteriophage (phage) therapyMouse model for acute UTIMultidrug-resistant (MDR) UPECPhage cocktailUrinary tract infection (UTI)Urinary tract microenvironmentUropathogenic Escherichia coli (UPEC)

Identifiers

PMID41714337
PMCPMC13018314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.