Evidence map›Paper›PMID 41714293›Full record

ArticleCancer medicine2026

Distinct Symptom Profiles in Younger and Older Patients With Cancer Receiving Chemotherapy.

Lisa Morse, Sandra Weiss, Christine S Ritchie, Melisa L Wong, Bruce A Cooper, Marilyn J Hammer, Yvette P Conley, Steven M Paul, Jon D Levine, Christine Miaskowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa MorseSchool of Nursing, University of California, San Francisco, California, USA.
Sandra WeissSchool of Nursing, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-6700-8734
Christine S RitchieDivision of Palliative Care and Geriatric Medicine, Massachusetts General Hospital Morgan Institute, Boston, Massachusetts, USA.
Melisa L WongDivision of Research, Kaiser Permanente Medical Group, Oakland, California, USA.ORCID https://orcid.org/0000-0001-6390-6959
Bruce A CooperSchool of Nursing, University of California, San Francisco, California, USA.
Marilyn J HammerDana Farber Cancer Institute, Boston, Massachusetts, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, California, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, California, USA.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, California, USA.

Funding

American Cancer SocietyNCI NIH HHS CA134900NIH HHS
6 · The paper itself

Abstract

backgroundCompared to younger patients, older patients report differences in the occurrence, severity, and distress of common symptoms associated with cancer and its treatment. PURPOSE: Identify subgroups of younger and older patients with distinct symptom burden profiles and evaluate for risk factors associated with these profiles.

methodsOncology outpatients (n = 1329) were dichotomized into younger (< 60 years) and older (≥ 60 years) groups. Data included demographic and clinical questionnaires and measures of global, cancer-specific, and cumulative life stress, resilience, and coping. Memorial Symptom Assessment Scale evaluated the occurrence of 38 common symptoms. Separate latent class analyses were done within each age group to identify distinct symptom profiles. Differences among latent classes in demographic and clinical characteristics, stress, resilience, and coping were evaluated.

resultsIn younger group (n = 730), four profiles were identified (i.e., All Low (28.8%), Moderate Physical and Lower Psychological (21.9%), Moderate Physical and Higher Psychological (34.6%), All High (14.7%)). Compared to All Low class, All High class was younger, more likely to be female, had a higher comorbidity burden, and a lower functional status, as well as higher stress and lower resilience scores. In the older group (n = 599), three profiles were identified (i.e., Low (34.4%), Moderate (47.9%), High (17.7%)). Compared to Low class, High class was more likely to be female, had a higher comorbidity burden and lower functional status, and received a more toxic chemotherapy regimen, as well as higher stress and lower resilience scores.

conclusionStudy is the first to use latent class analysis to identify distinct symptom burden profiles in younger versus older oncology patients. In the younger group, differences in the occurrence of psychological symptoms differentiated among the symptom burden profiles. While some of the risk factors were similar, within the older group, patients in the High symptom burden class used a higher number of disengagement coping strategies.

Indexed as

Antineoplastic AgentsNeoplasmsAdaptation, PsychologicalAdultAgedAged, 80 and overAge FactorsCoping SkillsFemaleHumansMaleMiddle AgedResilience, PsychologicalRisk FactorsStress, PsychologicalSurveys and QuestionnairesAntineoplastic Agentscancerchemotherapylatent class analysisolder adultspatient reported outcomesrisk factorssymptom burdensymptoms

Identifiers

PMID41714293
PMCPMC12920069

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.