ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2026
Sex differences in the effect of childhood adversity and coping strategies on psychosis expression: A TwinssCan study.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Examining the association between autistic traits and psychopathology in the general population: are there sex differences?European archives of psychiatry and clinical neuroscience · 2026Article
- The correlations between psychotic symptoms and childhood maltreatment as well as sex differences in adolescents with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
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Authors and funding
17 authors.
Funding
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Abstract
backgroundSex differences in psychosis pathoetiology are insufficiently understood. This study explores how childhood adversity (CA) and coping mechanisms relate to psychosis expression (PE) across males and females in the general population.
methodsData from the TwinssCan project (males:
resultsEmotional abuse (EA) was associated with increased total CAPE scores (T-CAPE), explaining the greatest variance among CA across sexes. Sex-specific effects showed that sexual abuse (SA) and physical abuse (PA) were linked to higher T-CAPE in females, whereas physical neglect (PN) was linked to higher T-CAPE in males. Passive-reacting was associated with increased T-CAPE, explaining the greatest variance among coping styles across both sexes. Sex-specific effects showed that, in females, seeking social support was linked to decreased T-CAPE, while emotional expression increased it. The only sex-shared interaction effect was between reassuring thoughts and emotional neglect (EN), associated with decreased T-CAPE. In females, social support (× PA/PN/EA), reassuring thoughts (× PA/PN), and palliative-reacting (× PN/PA) were associated with decreased T-CAPE, while passive-reacting (× EN) increased it. In males, avoidance (× SA/PA) and passive-reacting (× PN) were associated with increased T-CAPE.
conclusionsSex differences in the associations of PE with CA and coping underscore the necessity for sex-specific interventions that promote adaptive coping strategies.
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