Evidence map›Paper›PMID 41714174›Full record

Observational studyRenal failure2026

Outcomes and predictors of kidney failure in elderly patients with biopsy-proven IgA nephropathy.

Gabriel Ștefan, Nicoleta Petre, Adrian Zugravu, Simona Stancu

Abstract readObservational Study
In one paragraph

Observational study in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gabriel ȘtefanDepartment of Nephrology, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.ORCID 0000-0002-7336-5874
Nicoleta PetreDepartment of Pathology, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
Adrian ZugravuDepartment of Nephrology, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
Simona StancuDepartment of Nephrology, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical presentation and prognosis of immunoglobulin A nephropathy (IgAN) in older adults are poorly defined. We evaluated kidney and patient outcomes and predictors of progression in patients aged ≥60 years with biopsy-proven IgAN. We conducted a retrospective observational study in elderly patients diagnosed with primary IgAN between 2010 and 2024 at a tertiary center. Baseline clinical, laboratory, and histopathologic data were collected, and kidney biopsies were scored using the Oxford MEST-C (Mesangial hypercellularity, Endocapillary hypercellularity, Segmental glomerulosclerosis, Tubular atrophy/interstitial fibrosis, Crescents) classification. The primary outcome was a composite of end-stage kidney disease (ESKD) or death. Predictors of progression were assessed using Kaplan-Meier's analysis and Cox proportional hazards models. A total of 102 patients were included (median age 65 years; 73% male). Comorbidity burden was high (median Charlson Comorbidity Index 4), hypertension was prevalent (88%), and baseline kidney function was reduced (median estimated glomerular filtration rate (eGFR) 29.5 mL/min/1.73 m

Indexed as

Glomerulonephritis, IGAKidneyKidney Failure, ChronicAgedBiopsyComorbidityDisease ProgressionFemaleGlomerular Filtration RateHumansMaleMiddle AgedPrognosisProportional Hazards ModelsRetrospective Studiesagedchronic kidney disease progressioncomorbidityIgA nephropathyproteinuriarenin–angiotensin system inhibitors

Identifiers

PMID41714174
PMCPMC12922409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.