Evidence map›Paper›PMID 41714165›Full record

ArticleHemodialysis international. International Symposium on Home Hemodialysis2026

Success in Achieving Relatively High Targeted Convection Volumes in Multi-Ethnic Individuals Receiving Hemodiafiltration in Singapore.

Cindy Chan, Sugandha Saxena, Yan Yi Cheung, Nandakumar Mooppil, Akira Wu, Luca Neri, Jeffrey L Hymes, Franklin W Maddux, Benjamin E Hippen, Milind Nikam

Abstract read
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Article in Hemodialysis international. International Symposium on Home Hemodialysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Cindy ChanFresenius Medical Care AG, Global Medical Office, Hong Kong, Hong Kong.
Sugandha SaxenaFresenius Medical Care AG, Global Medical Office, Gurgaon, India.
Yan Yi CheungFresenius Medical Care AG, Global Medical Office, Singapore, Singapore.
Nandakumar MooppilFresenius Medical Care AG, Global Medical Office, Singapore, Singapore.
Akira WuMount Elizabeth Medical Centre, Singapore, Singapore.
Luca NeriFresenius Medical Care, Global Operational Artificial Intelligence and GenAI, Renal Research Institute, Vaiano Cremasco, Italy.
Jeffrey L HymesFresenius Medical Care Deutschland GmbH, Global Medical Office, Bad Homburg, Germany.
Franklin W MadduxFresenius Medical Care AG, Global Medical Office, Waltham, Massachusetts, USA.
Benjamin E HippenFresenius Medical Care AG, Global Medical Office, West Nashville, Tennessee, USA.
Milind NikamFresenius Medical Care, Global Medical Office, Dubai, UAE.ORCID https://orcid.org/0000-0002-5040-2310

Funding

fresenius medical care north america
6 · The paper itself

Abstract

backgroundHemodiafiltration has demonstrated improved outcomes in end-stage kidney disease, particularly with higher convection volumes than conventional hemodialysis. However, data on multiethnic Asian populations remain limited. This study evaluated the feasibility of achieving relatively high targeted convection volumes in hemodiafiltration in patients with end-stage kidney disease in Singapore.

methodsThis retrospective cohort analysis included 1404 patients undergoing hemodiafiltration between 2019 and 2023 at Fresenius Kidney Care clinics in Singapore using data obtained from the EuCliD database. Patients aged ≥ 18 years and on hemodiafiltration for > 3 months were included. Multivariate regression models were used to assess the factors associated with the attainment of convection volume.

resultsOver 291,000 hemodiafiltration sessions were analyzed. The mean convection volumes achieved were 21.8 L in post-dilution and 40.8 L in pre-dilution mode. Higher blood flow rates and treatment durations were significantly associated with relatively high targeted convection volume (p < 0.001). The distribution of convection volume was similar among Chinese, Indian, and Malay patients. Ethnicity, age, and vascular access were not significant predictors. Approximately 29% of the variation in achieved convection volume was attributable to center-related factors.

conclusionRelatively high targeted convection volume in hemodiafiltration was consistently achieved across a multiethnic cohort in Singapore. These findings support the feasibility of delivering high-volume hemodiafiltration to diverse real-world settings.

Indexed as

HemodiafiltrationKidney Failure, ChronicAdultAgedEthnicityFemaleHumansMaleMiddle AgedRetrospective StudiesSingaporeconvection volumehemodiafiltrationmulti‐ethnic Asian cohort

Identifiers

PMID41714165
PMCPMC13067205

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