Evidence map›Paper›PMID 41713945›Full record

ArticleThe European respiratory journal2026

EcN-Sj16-Exo ameliorates experimental asthma by inhibiting eosinophil extracellular trap formation

Xi Sun, Yao Liao, Ji Wu, Yuheng Liu, Dinghao Li, Zifeng Zhu, Yun Huang, Junwei Wu, Peiying Peng, Jin Su and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Xi SunKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Yao LiaoKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Ji WuDepartment of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yuheng LiuKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Dinghao LiDepartment of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Zifeng ZhuDepartment of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yun HuangDepartment of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Junwei WuKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Peiying PengMedical Department, Xizang Minzu University, Xianyang, China.
Jin SuKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Yingxin HeKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Mengxi YanglanKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Haiyi DengKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Feiyang CaoKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Junhao XuKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Zhongdao WuDepartment of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Lifu WangKingMed School of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China wanglf@gzhmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEosinophilic inflammation is a feature of allergic asthma, with eosinophil depletion shown to alleviate symptoms. Elevated levels of eosinophil extracellular traps (EETs) in bronchoalveolar lavage fluid (BALF) correlate with asthma severity. Sj16 is a protein from

methodsWe extracted exosomes secreted by

resultsEET formation is increased in sputum and BALF from patients with asthma. We demonstrate that Sj16 inhibits EET formation

conclusionOur findings suggest that EcN-Sj16-Exo represents a promising therapeutic approach in asthma, highlighting the potential of targeting EETs and N-WASP in asthma therapy.

Indexed as

AsthmaEosinophilsExosomesExtracellular TrapsWiskott-Aldrich Syndrome Protein, NeuronalAirway RemodelingAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalFemaleHumansLungMaleMiceMice, Inbred BALB CMice, Inbred C57BLOvalbuminWiskott-Aldrich Syndrome Protein, Neuronal

Identifiers

PMID41713945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.