Evidence map›Paper›PMID 41713639›Full record

ArticleExperimental hematology2026

TET2 loss enhances early response to inflammation in primitive and committed myeloid cells.

Matthew T Jenkins, Rebecca Dubin, Kirsten M Dickerson, Phoebe Nguyen, Jing Wang, Stanley C Lee, Rui Lu, Robert S Welner, Paul Brent Ferrell

Abstract read
In one paragraph

Article in Experimental hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew T JenkinsDepartment of Pharmacology, Vanderbilt University, Nashville, TN; Department of Medicine, Division of Hematology, Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.
Rebecca DubinDepartment of Medicine, Division of Hematology, Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.
Kirsten M DickersonDepartment of Medicine, Division of Hematology, Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.
Phoebe NguyenProgram in Cancer Biology, Vanderbilt University, Nashville, TN.
Jing WangDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN.
Stanley C LeeTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA.
Rui LuDivision of Hematology/Oncology and O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL.
Robert S WelnerDivision of Hematology/Oncology and O'Neal Comprehensive Cancer Center at the University of Alabama at Birmingham, Birmingham, AL.
Paul Brent FerrellDepartment of Medicine, Division of Hematology, Oncology & Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN; Department of Veterans Affairs, Nashville Veterans Affairs Hospital, Tennessee Valley Health Care, Nashville, TN. Electronic address: Brent.ferrell@vumc.org.

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jason Daniel Buenrostro · 2017 to 2026
$24.6M
Causes and consequences of genomic instability in myelodysplasiaR01CA292932 · NCI · FRED HUTCHINSON CANCER CENTER · PI Stanley Chun-Wei Lee · 2024 to 2026
$2.7M
MEF2D-Mediated Transcriptional Control of Acute Myeloid LeukemiaR01CA259480 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Rui Lu · 2022 to 2026
$1.7M
Role of bone marrow Tregs in maintaining stromal cell functionR01HL150078 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELNER, ROBERT S · 2020 to 2023
$1.5M
Delineating Drivers of Inflammation and Progression in Clonal HematopoiesisR56DK138826 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FERRELL, PAUL B · 2023 to 2023
$150k
BLRD VA I01 BX005991NCI NIH HHS R01 CA259480NCI NIH HHS R01 CA292932NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL150078NIDDK NIH HHS R56 DK138826
6 · The paper itself

Abstract

In vivo IL-1β exposure elicits enhanced hematopoietic stem cell (HSC) self-renewal and myeloid priming in Tet2

Indexed as

DNA-Binding ProteinsInflammationMyeloid CellsProto-Oncogene ProteinsAnimalsCell DifferentiationCell ProliferationDioxygenasesHematopoietic Stem CellsI-kappa B KinaseInflammasomesInterleukin-1betaMiceMice, KnockoutDioxygenasesDNA-Binding ProteinsI-kappa B KinaseIL1B protein, mouseInflammasomesInterleukin-1betaProto-Oncogene ProteinsTet2 protein, mouse

Identifiers

PMID41713639
PMCPMC13422744

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.