Evidence map›Paper›PMID 41713234›Full record

ArticleVaccine2026

Risk of spontaneous abortion after mRNA COVID-19 vaccination received just prior to or during pregnancy: Complete data from CDC COVID-19 vaccine pregnancy registry.

Sabrina A Madni, Christine K Olson, Lauren Head Zauche, Aliza Machefsky, Ansley V Waters, Reji Padathara-Mathew, Victoria Okereke, Andrea J Sharma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sabrina A MadniDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA. Electronic address: ovo9@cdc.gov.
Christine K OlsonDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA; U.S. Public Health Service Commissioned Corps, Rockville, MD, USA.
Lauren Head ZaucheDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA.
Aliza MachefskyDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Ansley V WatersDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA; Deloitte Consulting LLP, Arlington, VA, USA.
Reji Padathara-MathewDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA; Eagle Global Scientific, LLC, Atlanta, GA, USA.
Victoria OkerekeDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA; Deloitte Consulting LLP, Arlington, VA, USA.
Andrea J SharmaDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA; U.S. Public Health Service Commissioned Corps, Rockville, MD, USA.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Data on spontaneous abortion after COVID-19 vaccination during pregnancy are limited. We used data from the Centers for Disease Control and Prevention's COVID-19 Vaccine Pregnancy Registry (C19VPR) to assess risk of spontaneous abortion (SAB) among women receiving ≥1 mRNA COVID-19 vaccine up to 30 days before last menstrual period or during pregnancy. We calculated risk of SAB from 6 to 20 weeks' gestation using a fetuses-at-risk approach (n = 12,097). Pregnancies entered the risk pool at gestational age at vaccination. Risk of SAB in C19VPR was compared with pre-pandemic estimates. Cox proportional hazard models were used to compare risk by vaccine manufacturer. Cumulative risk of SAB was 10.79% (95%CI 10.01, 11.56). Risk of SAB among Moderna recipients was similar to Pfizer-BioNTech (adjusted hazard ratio 0.92; 95%CI 0.79, 1.07). Risk estimates of SAB were below or within pre-pandemic estimates. Generalizability may be limited due to homogeneity of the C19VPR cohort.

Indexed as

Abortion, SpontaneousCOVID-19COVID-19 VaccinesVaccinationAdultCenters for Disease Control and Prevention, U.S.FemaleHumansPregnancyProportional Hazards ModelsRegistriesSARS-CoV-2United StatesYoung AdultCOVID-19 VaccinesCOVID-19PregnancySpontaneous abortionVaccination

Identifiers

PMID41713234
PMCPMC12973310

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.