ArticleClinical and experimental pediatrics2026
Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia.
Article in Clinical and experimental pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPreeclampsia (PE) is a serious complication of pregnancy that affects the offspring and mothers. Those with a history of PE are at higher risk of future cardiometabolic diseases, the etiology of which remains uncertain. PURPOSE: To investigate the transcriptomic profiles of mothers and neonates to determine whether certain genes are commonly affected after shared exposure to PE.
methodsIn this observational study, pregnant mother-neonate dyads with PE and healthy normotensive mothers were prospectively recruited. We used RNA sequencing and bioinformatics analysis to characterize the transcriptomic profiles of maternal blood leukocytes (MBLs), cord blood leukocytes (CBLs), and umbilical arterial and venous endothelial cells (UAECs and UVECs, respectively). These results were further validated using real-time reverse transcription polymerase chain reaction.
resultsGene expression during the perinatal/peripartum period was context-dependent in patients with PE and involved various signaling pathways. Inflammation- and immune-related signaling pathways in maternal blood and coagulation-related signaling pathways in cord blood were upregulated in the PE group compared to those in the control group. Ten differentially expressed genes were commonly affected in MBLs and CBLs. Maternal LMNA and CBL levels of MAST4 differentiated those with PE from those with normotension in a gestational-age-adjusted model. Maternal levels of ADAMTS2 and CBL levels of ADAMTS2, GABRE, and MMP8 independently determined neonatal gestational age and birth weight. CBL MMP8 levels independently determined maternal blood pressure. However, the transcriptomic profiles of endothelial cells differ from those of blood leukocytes. Heart morphogenesis-related signaling pathways in UAECs and leukocyte cell-cell adhesion-related signaling pathways in UVECs were more involved in PE. The messenger RNA levels of FAT3 and SLC25A18 in the UAECs were higher in the PE group than in the control group.
conclusionPerinatal and peripartum genes in PE are expressed in a context-dependent manner via diverse signaling pathways, with little overlap between mothers and neonates.
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