Evidence map›Paper›PMID 41713191›Full record

ReviewCurrent opinion in genetics & development2026

Polycomb-mediated 3D chromatin interactions in gene regulation.

Sumin Kim, Miles K Huseyin, Anders S Hansen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in genetics & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sumin KimDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA. Electronic address: https://twitter.com/@suminkim.bsky.social.
Miles K HuseyinDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.
Anders S HansenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA. Electronic address: ashansen@mit.edu.

Funding

Resolving transcription factor target search mechanismsR01CA300848 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Anders Sejr Hansen · 2024 to 2026
$2.9M
DYNAMIC BOTTOM-UP DISSECTION OF CHROMATIN LOOPING AND GENE REGULATIONDP2GM140938 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2020 to 2020
$2.3M
An integrated toolkit for real-time analysis of coupled nascent transcriptionR01EB035127 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Anders Sejr Hansen · 2024 to 2026
$1.3M
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancerR33CA257878 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2021 to 2023
$1.1M
Ultra-high resolution 3D genome maps for multiple human tissuesR03OD038390 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANSEN, ANDERS SEJR, LIU, JIE · 2024 to 2024
$309k
Elucidating the Dynamics and Function of Long-Range Polycomb InteractionsF32GM156065 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Sumin Kim · 2025 to 2026
$155k
NCI NIH HHS R01 CA300848NCI NIH HHS R33 CA257878NIBIB NIH HHS R01 EB035127NIGMS NIH HHS DP2 GM140938NIGMS NIH HHS F32 GM156065NIH HHS R03 OD038390
6 · The paper itself

Abstract

The Polycomb repressive system is a conserved, chromatin-based transcriptional regulator that is essential for the normal development of multicellular organisms. Polycomb-group proteins catalyze repressive histone modifications and organize 3D chromatin interactions. While the relationship between Polycomb-deposited histone modifications and gene repression is well-established, how Polycomb-mediated 3D chromatin interactions contribute to gene regulation remains poorly understood. In this review, we discuss current insights into the formation of these interactions and potential models for how they contribute to Polycomb-dependent gene regulation.

Indexed as

ChromatinGene Expression RegulationPolycomb-Group ProteinsAnimalsHistonesHumansChromatinHistonesPolycomb-Group Proteins

Identifiers

PMID41713191
PMCPMC13182140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.