High-frequency sonochemical conversion of hydrophobic polyphenols into functional nanoparticles for bioengineering.

Han Yang, Zhiliang Gao, Menglin Chen, Mengqi Liu, Xinxin Han, Jiwei Cui, Peiyu Zhang

Abstract read

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Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Han YangKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Zhiliang GaoShandong Key Laboratory of Magnetic Field-Free Medicine & Functional Imaging, Research Institute of Magnetic Field Free Medicine & Functional Imaging, National Medicine-Engineering Interdisciplinary Industry-education Integration Innovation Platform, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

Menglin ChenKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Mengqi LiuKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Xinxin HanKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Jiwei CuiKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Peiyu ZhangKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China. Electronic address: pyzhang@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyphenols are natural compounds with diverse biological activities; however, their practical applications are often limited by poor solubility and chemical instability. In this study, a high-frequency ultrasound-assisted approach is developed for the preparation of polyphenol nanoparticles (NPs), producing well-dispersed and uniformly sized particles. The method exhibits excellent versatility and can be applied to a wide range of polyphenol precursors, including 1,8-dihydroxynaphthalene (1,8-DHN). Additionally, the integration of an ultrasound-assisted Fenton reaction markedly accelerates polyphenol polymerization and NP nucleation. The resulting NPs demonstrate outstanding antioxidant capacity, effectively scavenging intracellular reactive oxygen species (ROS). Notably, DHN-derived NPs show strong antibacterial activity, efficiently eliminating both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria at relatively low concentrations. Overall, this study presents a green, simple, and scalable strategy for fabricating multifunctional polyphenol NPs. The synergistic antioxidant and antibacterial properties of these NPs highlight their broad potential in biomedical engineering, providing a valuable platform for the design of next-generation bioactive nanomaterials.

Indexed as

BioengineeringHydrophobic and Hydrophilic InteractionsNanoparticlesPolyphenolsUltrasonic WavesAnti-Bacterial AgentsAntioxidantsEscherichia coliReactive Oxygen SpeciesStaphylococcus aureusAnti-Bacterial AgentsAntioxidantsPolyphenolsReactive Oxygen SpeciesAntibacteriaAntioxidantHigh-frequency ultrasoundNanoparticlesPolyphenol

Identifiers

PMID41713121

DOI10.1016/j.ultsonch.2026.107766

PMCPMC12930172

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.