Evidence map›Paper›PMID 41712939›Full record

ArticleObstetrics and gynecology2026

First-Trimester Bleeding and the Risk of Pregnancy Loss in a Prospective Cohort.

Alexandra C Sundermann, Elizabeth A Jasper, Paulina E Chumakov, Suchita E Kumar, Katherine E Hartmann, Digna R Velez Edwards

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics and gynecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra C SundermannDivision of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, and the Department of Biomedical Informatics, Vanderbilt University Medical Center, and the Vanderbilt University School of Medicine, Nashville, Tennessee; and the Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky.
Elizabeth A Jasper
Paulina E Chumakov
Suchita E Kumar
Katherine E Hartmann
Digna R Velez Edwards

Funding

Consequences and Course of Uterine Fibroids in PregnancyR01HD043883 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2004 to 2008
$3.1M
Non-steroidal anti-inflammatory use and miscarriageR01HD049675 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2006 to 2010
$2.6M
Building Interdisciplinary Research Careers in Women's HealthK12AR084232 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AMY S MAJOR, Digna R Velez Edwards · 2023 to 2026
$1.3M
Transdisciplinary approaches for maternal-child health: a focus on gestational weight gainK01DK140644 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Elizabeth A Jasper · 2025 to 2026
$285k
American Water Works Association 2579Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD043883Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD049675NIAMS NIH HHS K12 AR084232NIAMS NIH HHS K12AR084232NICHD NIH HHS R01 HD043883NICHD NIH HHS R01 HD049675NIDDK NIH HHS K01 DK140644
6 · The paper itself

Abstract

Vaginal bleeding in the first trimester is common, but our understanding of how bleeding relates to the risk of pregnancy loss is limited. In a prospective cohort study, participants provided information on bleeding episodes during early pregnancy and underwent a first-trimester research ultrasonogram. Among 5,425 participants, 25.0% of participants reported first-trimester bleeding, and 12.0% of pregnancies ended in loss. Bleeding was not associated with risk of pregnancy loss (hazard ratio [HR] 0.89, 95% CI, 0.75-1.07). First-trimester bleeding coupled with ultrasound measurements that lagged more than 5 days behind last menstrual period (LMP) dating was associated with increased risk (HR 2.72, 95% CI, 2.10-3.53). These findings indicate that reassurance is appropriate for most patients experiencing first-trimester bleeding when ultrasound measurements align with LMP.

Identifiers

PMID41712939
PMCPMC12951396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.