Evidence map›Paper›PMID 41712780›Full record

ArticleJournal of the American Chemical Society2026

PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington's Disease.

Po-Chao Lu, Yung-An Huang, Niaz Wali, Mei-Chun Tseng, Ruei-Yu He, Yijuang Chern, Tzu-Tang Wei, Jiun-Jie Shie, Joseph Jen-Tse Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Po-Chao LuInstitute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Yung-An HuangInstitute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Niaz WaliInstitute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Mei-Chun TsengInstitute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Ruei-Yu HeInstitute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
Yijuang ChernInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Tzu-Tang WeiDepartment and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Jiun-Jie ShieInstitute of Chemistry, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-0856-214X
Joseph Jen-Tse HuangInstitute of Chemistry, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-4847-7126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the

Indexed as

Huntingtin ProteinHuntington DiseaseAnimalsDisease Models, AnimalHumansMiceProtein AggregatesProteolysisProteolysis Targeting ChimeraHuntingtin ProteinProtein AggregatesProteolysis Targeting Chimera

Identifiers

PMID41712780
PMCPMC12964395

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.