Evidence map›Paper›PMID 41712646›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Extracellular stiffness regulates cell fate determination and drives the emergence of evolutionary novelty in the teleost heart.

Sho Matsuki, Yusei Inoue, Ryuta Watanabe, Toshiyuki Mitsui, Yuuta Moriyama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sho MatsukiDepartment of Physical Sciences, College of Science and Engineering, Aoyama Gakuin University, Kanagawa 252-5258, Japan.ORCID 0009-0003-2676-7912
Yusei InoueDepartment of Physical Sciences, College of Science and Engineering, Aoyama Gakuin University, Kanagawa 252-5258, Japan.
Ryuta WatanabeDepartment of Physical Sciences, College of Science and Engineering, Aoyama Gakuin University, Kanagawa 252-5258, Japan.ORCID 0009-0001-5223-7793
Toshiyuki MitsuiDepartment of Physical Sciences, College of Science and Engineering, Aoyama Gakuin University, Kanagawa 252-5258, Japan.ORCID 0000-0002-5465-4742
Yuuta MoriyamaDepartment of Physical Sciences, College of Science and Engineering, Aoyama Gakuin University, Kanagawa 252-5258, Japan.ORCID 0000-0002-2853-8051

Funding

JSPS KAKENHI Grant-In-Aid for Scientific Research (C) 20K06773JSPS KAKENHI Grant-In-Aid for Scientific Research (C) 25K09730
6 · The paper itself

Abstract

The diversification of life is driven by the acquisition of new phenotypic traits, known as evolutionary novelties. While some genetic mechanisms underlying such traits have been identified, the role of physical properties of cellular and extracellular components remains largely unexplored. Here, we show that the evolution and development of the bulbus arteriosus (BA)-a teleost-specific, smooth muscle-rich heart outflow tract-is regulated by the mechanical properties of its extracellular environment. Specifically, we demonstrate that the teleost-specific extracellular matrix gene

Indexed as

Biological EvolutionExtracellular MatrixFishesHeartAnimalsCell DifferentiationElastinMyocardiumMyocytes, CardiacElastinECMelastinheartstiffness

Identifiers

PMID41712646
PMCPMC12933065

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.