ArticleProceedings of the National Academy of Sciences of the United States of America2026
Mfsd2a is important for maintaining epidermal homeostasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- MFSD2A in health and disease: lysolipid transport, barrier physiology, and translational boundaries.Molecular biomedicine · 2026Review
- Comprehensive Metabolomic Profiling of Skin Lesions from Psoriasis Patients Reveals Disease Signatures.International journal of biological sciences · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The skin epidermis is a multilayered lipid rich organ completely reliant on exogenous delivery and uptake of the essential fatty linoleate for the synthesis of acylceramides required for barrier function. Disruption of the epidermal skin barrier is a common clinical feature for prevalent diseases such as atopic dermatitis and psoriasis. The granulosum layer of the epidermis contains specialized secretory keratinocytes that synthesize and secrete lamellar bodies (LB), making it likely that this epidermal layer has a high demand for phosphatidylcholine. While the pathway for acylceramide biosynthesis and roles in barrier formation has been largely elucidated, the mechanisms by which keratinocytes acquire phospholipid for the demands of lipid barrier maintenance and repair are not entirely understood. Here, we demonstrate that Mfsd2a, a lysophosphatidylcholine (LPC) transporter, is predominantly expressed in keratinocytes and mediates the uptake of a plasma-derived LPC fluorescent probe. Epidermal-specific deficiency of Mfsd2a in mice resulted in dermatitis and defective desquamation of the epidermis, and inducible deletion of
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